Fig. 5: SignalingProfiler 2.0 phenotypic inference parameters tuning (Step 3).
From: SignalingProfiler 2.0 a network-based approach to bridge multi-omics data to phenotypic hallmarks
A For each Step 3 parameter, the average Precision, Recall, and Root Mean Squared Error (RMSE) with respect to the phenotypic gold standard (Supplementary Data 1) are reported across 96 conditions. Optimal parameter values are reported in red. White and dark gray represent minimum and maximum parameter values. B Violin plot illustrating the inferred activity distribution of 10 metformin-treatment-associated phenotypes across the 96 technical conditions of the benchmarking of SignalingProfiler 2.0 Step 3. The color of each violin corresponds to the expected activity in the phenotypic gold standard (Supplementary Data 1). C Scatter plot displaying the distribution of the combined score across each of the 96 technical conditions evaluated to assess their fit to the phenotypic gold standard (Supplementary Data 1).
