Fig. 6: SignalingProfiler 2.0 parameters tuning validation and EGF use case.
From: SignalingProfiler 2.0 a network-based approach to bridge multi-omics data to phenotypic hallmarks
A, B For training and validation datasets, the bar plot reports the Precision and Recall with respect to the protein and phenotypic gold standard (A), and the percentage of edges representing experimentally quantified phosphorylations (B). C–E SignalingProfiler 2.0 application on data from EGF-stimulated HeLa cell lines. C Cartoon of experimental strategy (panel a) and SignalingProfiler 2.0 results (panel b). D Bar plot of the phenotypic modulation upon EGF stimulation inferred by SignalingProfiler 2.0. Blue and red bars represent inactive and active phenotypes, respectively. E Functional circuit extracted from the EGF-model impacting cell cycle and proliferation.
