Fig. 5: Classification of dose- and time-dependent glucose-responsive molecules in liver. | npj Systems Biology and Applications

Fig. 5: Classification of dose- and time-dependent glucose-responsive molecules in liver.

From: Time and dose selective glucose metabolism for glucose homeostasis and energy conversion in the liver

Fig. 5

Distribution of ED50 (horizontal axis) and T1/2 (vertical axis) for dose- and time-dependent glucose-responsive molecules including metabolites (Brown), Enzyme RNAs (Green), and insulin signaling molecules (Purple). The directions of the scatter marks represented their responsive patterns (up: increase, down: decrease). Histograms of these indicators are on the right (T1/2) and upper (ED50) part of the scatter plot. Red dotted lines suggest the calculated threshold of ED50 (vertical, 1.2 g/kg) and T1/2 (horizontal, 20 min) using the triangle method.

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