Fig. 1: Illustration comparing four distinct dosing paradigms in cell-cell competition models in cancer. | npj Systems Biology and Applications

Fig. 1: Illustration comparing four distinct dosing paradigms in cell-cell competition models in cancer.

From: A mathematical framework for comparison of intermittent versus continuous adaptive chemotherapy dosing in cancer

Fig. 1

Cytotoxic chemotherapy at maximum tolerated dose (MTD) results in early extinction of the sensitive cell population. Two adaptive therapy models are shown: intermittent adaptive therapy (resulting from on-off dose modulation aka “dose-skipping") and continuous adaptive therapy (resulting from dose modulation to maintain a given tumor volume). Finally, fixed low dose therapy in the antiproliferative range of drug action is shown and is considered a type of metronomic therapy. Created with Biorender.com.

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