Fig. 2: Cell-cell competition model across parameter spaces.
A Conceptual representation of cell-cell competition model. The growth rates of the sensitive and resistant populations are given by rx and ry respectively. α and β are the competition parameters of y on x and x on y respectively. The carrying capacity of each species is normalized to 1. Drug dose is given by rd and acts only to decrease the sensitive species. B–F Vector fields corresponding to different relative competition strengths between the sensitive and resistant cell populations without drug. The nullclines are plotted in orange. The equilibrium states are shown as illustrations in the upper right insets and areas where \({x}^{{\prime} } > 0\) and \({y}^{{\prime} } < 0\) are shaded blue.
