Fig. 3: Simulation of intermittent adaptive therapy for α < 1, β > 1 showing three possible outcomes. | npj Systems Biology and Applications

Fig. 3: Simulation of intermittent adaptive therapy for α < 1, β > 1 showing three possible outcomes.

From: A mathematical framework for comparison of intermittent versus continuous adaptive chemotherapy dosing in cancer

Fig. 3

A Phase space for drug on and drug off with 3 trajectories of adaptive therapy plotted (light blue, pink, and dark blue) under the same simulation parameters with different initial conditions. Nullclines are shown as dashed orange lines. B Sensitive extinction time course corresponding to the dark blue trajectory in phase space shown in (A). C Sensitive/resistant equilibrium time course corresponding to the pink trajectory in phase plane shown in (A). D Resistant extinction time course corresponding to the light blue trajectory in phase space shown in (A).

Back to article page