Fig. 4: SRA analysis. | npj Systems Biology and Applications

Fig. 4: SRA analysis.

From: Splicing junction-based classifier for the detection of abnormal constitutive activation of the KEAP1-NRF2 system

Fig. 4

a SRA Overview: Exploration of runs with NRF2 score of at least 30 and their associated tissue of study. Runs are plotted by NRF2 score and colored by the tissue analyzed. b Results of our classifier on project SRP173213. The NRF2 score increases with the duration of LPS treatment in monocytes, reflecting the NRF2-mediated activation observed during LPS-induced inflammatory responses in monocytes. c Results of our classifier on project SRP066737. Our classifier successfully differentiated between A549 with and without NFE2L2 knockdown. d Results of our classifier on project SRP067630. The Caki-2 cell line was predicted to have constitutive activation across the study. e Results of our classifier on project SRP063938. Our classifier was capable of distinguishing between different KEAP1 mutations: the missense mutation in Huh1 and the silent mutation in Huh7.

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