Fig. 3: The co-expression networks highlight core genes in several inflammatory skin diseases. | npj Systems Biology and Applications

Fig. 3: The co-expression networks highlight core genes in several inflammatory skin diseases.

From: Integrative systems biology framework discovers common gene regulatory signatures in mechanistically distinct inflammatory skin diseases

Fig. 3

A Different co-expression networks were constructed with the same parameters through WGCNA for eight inflammatory skin diseases with the corresponding number of nodes and edges. The networks are acne (320 nodes and 264 edges), atopic dermatitis (AD; 3259 nodes and 13,716 edges), actinic keratoses (AK; 572 nodes and 1249 edges), contact dermatitis (CD; 697 nodes and 763 edges), hidradenitis suppurativa (HS; 4162 nodes and 420,422 edges), irritant contact dermatitis (ICD; 478 nodes and 698 edges), psoriasis (PS; 5465 nodes and 132,849 edges), and rosacea (RS; 1825 nodes and 11,810 edges). B The power-law distribution of eight co-expression networks to measure their scale-freeness. C The table illustrates the total number of nodes and connected components to determine the network exposibility for each co-expression network. D The network exposibility distribution for eight co-expression networks to illustrate the robust networks to study further with parameter (network exposibility > 10). E The core co-expression network among psoriasis, hidradenitis suppurativa, and atopic dermatitis. F The gene ontology analysis of enriched pathway of core co-expression network genes among PS, HS, and AD (P-value < 0.05). G The core co-expression network among HS, AD, and RS. H The gene ontology analysis of enriched pathway of core co-expression network genes among hidradenitis suppurativa, atopic dermatitis, and rosacea (P-value < 0.05).

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