Fig. 6: The identification of shared significant regulator proteins in four inflammatory skin diseases. | npj Systems Biology and Applications

Fig. 6: The identification of shared significant regulator proteins in four inflammatory skin diseases.

From: Integrative systems biology framework discovers common gene regulatory signatures in mechanistically distinct inflammatory skin diseases

Fig. 6

A The Venn diagram represents the distribution of shared and unique significant proteins in each PPI network. Interestingly, IKZF1 protein is shared among hidradenitis suppurativa (HS), atopic dermatitis (AD), and rosacea (RS) with high network centrality values. B The six drugs are known to target IKZF1. C The IKZF1 acts as a master regulator by interacting with 19 targets, 62 proteins, and 88 co-expressed genes. Activities of these proteins can be altered by targeting IKZF1 with the drug Lenalidomide. D–F The expression profile of IKZF1 interacting partners; 19 targets, 62 proteins, and 88 co-expressed genes in four inflammatory skin diseases including HS, PS, AD, and RS.

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