Fig. 13: RhoA/ROCK signaling.
From: A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis
Myelin-associated inhibitory substances from oligodendrocytes initiate Rho/ROCK signaling in motor neurons, leading to inhibition of cell growth and axonal degeneration, thereby destabilizing the NMJ. Double-sided orange rectangle represents a molecular pathway within a cell; black arrow represents signal propagation; small dark blue rectangle represents a protein or enzyme; light blue pentagram represents the ligand; and, green step arrow represents a receptor.
