Fig. 14: Mechanisms of mitophagy in neurons.
From: A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis
Mutant SOD aggregates inhibition ETC signaling and autophagy via ERK/STAT3 signaling and Atg12 suppression, respectively. Autophagy suppression leads to neuronal cell death. ETC Electron transport chain, ERK Extracellular signal-regulated kinase, STAT3 signal transducer and activator of transcription,- Atg12 Autophagy related gene 12, TPSO Translocator protein. Double-sided orange rectangle represents a molecular pathway within a cell; black arrow represents signal propagation; red flat arrow represents inhibition of signal propagation; small dark blue rectangle represents a protein or enzyme; small pink rectangle represents mutated protein/enzyme; and, purple lozenge represents mRNA.
