Fig. 6: Agrin-MuSK-LPR4 signaling pathway in skeletal muscle cell.
From: A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis
Agrin from motor neuron terminal initiates agrin-MuSK-LPR4 signaling leading to muscle atrophy via Rho-ROCK signaling in skeletal muscle cells. MuSK Muscle-specific kinase, LPR4 Low-density lipoprotein receptor-related protein 4, RhoA Rat sarcoma homolog family member A, ROCK Rho-associated protein kinase. Double-sided orange rectangle represents a molecular pathway within a cell; black arrow represents signal propagation; red flat arrow represents inhibition of signal propagation; small dark blue rectangle represents a protein or enzyme; light blue pentagram represents the ligand; and, green step arrow represents a receptor.
