Fig. 7: Role of autophagy in neuronal death.
From: A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis
Mutations in genes such as SQSSRM1, C9orf72 and OPTN in ALS disrupt autophagy signaling leading to neuronal degeneration and death. mTORC1 mammalian target of rapamycin C1, OPTN optineurin, LC3 light chain 3, ULK Unc-51-like kinase, PolyGR Poly-glycine-arginine, WDR41 tryptophan-aspartic acid (W-D) repeat domain 41, SMCR8 Smith-Magenis syndrome chromosome region, candidate 8. Double-sided orange rectangle represents a molecular pathway within a cell; black arrow represents signal propagation; red flat arrow represents inhibition of signal propagation; small dark blue rectangle represents a protein or enzyme; small pink rectangle represents mutated protein/enzyme; light blue pentagram represents the ligand; and, green step arrow represents a receptor.
