Fig. 9: Tweak/Fn14 signaling.
From: A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis
IFN-γ from motor neuron terminal induces Tweak production in astrocytes, which upregulates expression of MuRF1 in skeletal muscle cell. MuRF1 inhibition of autophagy in skeletal muscle cell causes muscle atrophy. IFN-γ Interferon-γ, UPS ubiquitin-proteasome system. Double-sided orange rectangle represents a molecular pathway within a cell; black arrow represents signal propagation; red flat arrow represents inhibition of signal propagation; small dark blue rectangle represents a protein or enzyme; purple lozenge represents mRNA; light blue pentagram represents the ligand; and, green step arrow represents a receptor.
