Table 2 Summary of potential therapeutic molecular targets
From: A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis
Molecular Target | Cell Type | Biological Process | Reference |
|---|---|---|---|
ATG7 | Motor neurons | Neuronal Degeneration/Death | |
ROCK | Motor neurons | Neuronal Degeneration/Death | |
Manganese superoxide dismutase | Skeletal muscle | Muscle Atrophy | |
Dynactin1a | Motor neurons | Neuronal Degeneration/Death | |
Mitochondrial uncoupler protein (UCP1) | Skeletal muscle | Muscle Atrophy | |
CTGF/CCN2 | Skeletal muscle, astrocytes and motor neurons | Muscle Atrophy, Neuronal Degeneration/Death | |
SARM-1 | Motor neurons | Neuronal Degeneration/Death | |
Oxidation resistance 1 (Oxr1) protein | Motor neurons | Neuronal Degeneration/Death | |
PDK4 | Skeletal muscles | Muscle Atrophy | |
IL-1α, TNF and C1q | Microglia | Neuroinflammation | |
HDAC4 | Skeletal muscle cells | Muscle Atrophy | |
NOX2 | Motor neurons | Neuronal Degeneration/Death | |
KIF5A | Astrocytes | Neuronal Degeneration/Death | |
5-Hydroxytryptamine (5-HT) | Motor neurons | Neuronal Degeneration/Death |
