Fig. 3: Differentially regulated intermediate EMT state genes identified via RNA velocity. | npj Systems Biology and Applications

Fig. 3: Differentially regulated intermediate EMT state genes identified via RNA velocity.

From: Modeling the dynamics of EMT reveals genes associated with pan-cancer intermediate states and plasticity

Fig. 3

a Annotation of cellular locations for genes differentially regulated in the intermediate state, identified through differential velocity (DV) analysis. b Annotation of the EMT properties of DV genes by comparison with three EMT marker gene sources. EMP: epithelial–mesenchymal plasticity. c Examples of DV genes upregulated in intermediate EMT states across different conditions. Solid line represents the dynamical model fit; dashed line represents the inferred steady state. LAMC2 is upregulated across samples from different cell lines & stimuli. d ITGB4 is upregulated only with a specific stimulus: TGF-β. e ITGB4 is upregulated only in a specific tumor type: ovarian cells OVCA420.

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