Fig. 6: SFN is identified as a marker of intermediate EMT in an analysis of dose-dependent EMT. | npj Systems Biology and Applications

Fig. 6: SFN is identified as a marker of intermediate EMT in an analysis of dose-dependent EMT.

From: Modeling the dynamics of EMT reveals genes associated with pan-cancer intermediate states and plasticity

Fig. 6

a MCF10A cells were analyzed separately and exhibit a linear trajectory across EMT states. b For each MCF10A cell state, the top 25 differentially expressed genes colored by gene set annotation. c Model fit following parameter inference: data vs. trajectory simulations, with simulation parameters sampled from the posterior distribution. d Comparison of posterior parameter distributions, with the MCF10A sample highlighted in green. Other distributions are replicated from Fig. 4d, shown in different colors here to highlight stimulation by TGF-β.

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