Table 1 The experimental value of Closure in response to interventions in the absence of ABA and the corresponding predictions of four models

From: Automated model refinement using perturbation-observation pairs

  1. “CA” refers to constitutive activation or supply, which is implemented in the model by fixing the node in the ON state, “KO” refers to knockout, implemented by fixing the node in the OFF state. The interventions are listed in the decreasing order of the number of relevant perturbation-observation pairs, indicated in the last row. The model entries indicate the categorization from lack of closure (0) to closure (1) described in the Methods. To aid the comparison of the models in recapitulating the experimentally observed closure responses, the background of each entry is color-coded as white (agreement), yellow (partial agreement), or red (disagreement).
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