Table 4 Illustrative biological predictions that can be made based on the GA-refined models of ABA-induced closure
From: Automated model refinement using perturbation-observation pairs
Context | Prediction |
|---|---|
Constitutive activation of ABI1 in the presence of ABA | The aquaporin channels will not activate (will not open) |
Externally provided ROS in the absence of ABA | The malate concentration decreases below threshold. |
PA is produced | |
The microtubules are depolymerized | |
Disruption of aquaporins (pip2;1 KO) in the presence of ABA | Lack of NO production |
No cADPR production | |
PLDδ is not activated | |
Externally provided ROS in the absence of ABA | PP2CA is active |
Externally provided ROS, knockout of RCARs receptors, in the presence of ABA | PP2CA is active |
Externally provided cADPR in the absence of ABA | pHc increases to a lesser extent than in response to ABA |
No ROS production | |
PA is produced | |
Externally provided 8-nitro-cGMP in the absence of ABA | pHc increases to a lesser extent than in response to ABA |
No ROS production | |
PA is produced | |
Externally provided Ca2+ in the absence of ABA | No ROS production |
