Table 5 The agreement functions used in boolmore

From: Automated model refinement using perturbation-observation pairs

Category

Agreement function (0 ≤ x ≤ 1)

Examples

ON

f(x) = x

ABA=1, observing pHc.

Some/ON

f(x) = 2x (x < 0.5)

f(x) = 1 (x ≥ 0.5)

NO CA, observing Closure. The closure (i.e., reduction in the stomatal aperture) in various reported experiments varied between 30% and 60% of that in response to ABA.

Some

f(x) = 4x (x < 0.25)

f(x) = 1 (0.25 ≤ x < 0.75)

f(x) = 4-4x (x ≥ 0.75)

8-nitro-cGMP CA, observing Closure. The experimental closure response was around 25% of the response to ABA.

OFF/Some

f(x) = 1 (x < 0.5)

f(x) = 2-2x (x ≥ 0.5)

ABA = 1, S1P/PhytoS1P KO, observing Closure. S1P was depleted using a chemical, whose effect may reduce over time. Thus, the experimentally observed weak closure (instead of the expected lack of closure) may be due to the dissipation of the depletion.

OFF

f(x) = 1-x

NO CA, observing ROS.

  1. The agreement function indicates the average value of the respective node in the trap spaces of the model on the x-axis and the agreement on the y-axis. These are used for hierarchy-based scoring.