Fig. 4: Overview of A2780 GEM reconstruction and modeling.
From: Modeling the metabolic response of A2780 ovarian cancer cells to gold-based cytotoxic drugs
A Scheme of the genome-scale metabolic reconstruction of A2780 cells. B Expression level threshold adopted here and its impact on metabolites, reactions, cancer-related reactions and biomass reaction flux. C Venn diagram showing the pool of shared reactions between the four context-specific models. D Schematic representation of the main metabolic nodes around the compound Fucose. E Comparison between measured and simulated changes in specific metabolites for each treatment.
