Fig. 2: TransComp-R identifies T2D PCs predictive of AD outcomes. | npj Systems Biology and Applications

Fig. 2: TransComp-R identifies T2D PCs predictive of AD outcomes.

From: Translational disease modeling of peripheral blood identifies type 2 diabetes biomarkers predictive of Alzheimer’s disease

Fig. 2

a AD PCs were separated by cohort, with variance explained in AD. b Selection of PCs using a LASSO model incorporating sex and age demographics from the AD datasets. The model was run across twenty random rounds of ten-fold cross-validation. PCs consistently determined significant across both AD cohorts from the GLM regression were further analyzed. c Principal component plots of AD scores on selected T2D PCs separating AD and control outcomes in AD cohort 1 and d AD cohort 2. Each T2D PC is represented by the percent variance explained in AD.

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