Fig. 4: Comparison of global gene expression and AD-predictive T2D PCs. | npj Systems Biology and Applications

Fig. 4: Comparison of global gene expression and AD-predictive T2D PCs.

From: Translational disease modeling of peripheral blood identifies type 2 diabetes biomarkers predictive of Alzheimer’s disease

Fig. 4

a AD and T2D log2 fold change plot of all shared 11,455 genes, b AD and T2D log2 fold change plot filtered by gene expressions with the top 50 and bottom 50 loadings of T2D PC2. c Scores of T2D PC2 separated by sex and disease condition. A Mann–Whitney test adjusted by Benjamini–Hochberg was used to determine statistical significance. The distribution of the data is annotated by the mean and interquartile ranges.

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