Fig. 6: Translating blood-predictable signatures to the brain. | npj Systems Biology and Applications

Fig. 6: Translating blood-predictable signatures to the brain.

From: Translational disease modeling of peripheral blood identifies type 2 diabetes biomarkers predictive of Alzheimer’s disease

Fig. 6

a Method of testing blood-derived data predictability in the brain (Illustration from biorender.com). b Z-score of significant AD-associated genes identified in the human hippocampal dataset (Mann–Whitney adjusted by Benjamini–Hochberg, p adjusted <0.20). c PLS-DA model using significant genes to predict AD status. AD groups are labeled by APOE genotype, Braak stage, and MMSE. d Loading variables LV1 and LV2 for the model are presented. A VIP > 1 is annotated with a star, and the color of the loading bar represents the highest contribution to the specific class by the respective gene.

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