Fig. 8: Validation of TransComp-R findings with single-cell RNA-seq analysis. | npj Systems Biology and Applications

Fig. 8: Validation of TransComp-R findings with single-cell RNA-seq analysis.

From: Translational disease modeling of peripheral blood identifies type 2 diabetes biomarkers predictive of Alzheimer’s disease

Fig. 8

a Analysis pipeline with the scRNA-seq data to identify cell types and differentially expressed genes. (Illustration from biorender.com). b UMAP and projected clusters of the 12 clustered scRNA cell types from. c UMAPs annotated by how well the top and bottom 50 genes from T2D PC2 are expressed in each cell type. Quantification performed by the module score (left) and percentage of the total genes of the top and bottom 50 genes from T2D PC2 (right).

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