Table 1 Observed versus simulated patient response rates to epcoritamab, mosunetuzumab, and loncastuximab-riensine monotherapy treatments

From: QSP modeling of loncastuximab tesirine with T-cell-dependent bispecific antibodies guides dose-regimen strategy

 

Epcoritamab

Mosunetuzumab

Loncastuximab tesirine

Response

Sims

Obs

Sims

Obs

Sims

Obs

CR

43.68

43

18.63

20

28.05

29

PR

25.05

27

19.06

17

32.33

29

SD

3.21

4

7.92

7

16.7

17

PD

28.05

27

54.39

56

22.91

25

  1. CR complete response, PR partial response, SD stable disease, PD progressive disease.
  2. Response classifications are based on ref. 48.
  3. Epcoritamab clinical data from n = 157 r/r NHL patients46.
  4. Mosunetuzumab clinical data from n = 129 aggressive-NHL patients47.
  5. Loncastuximab tesirine clinical data from n = 145 r/r DLBCL patients16.