Fig. 5: Desensitization controls dose–response curve separation.
From: Modeling the use of transient ligand binding information by AMPA receptors
a Steady state binding and peak current dose–response curves with base (rates used for AMPAR so far) and factor-multiplied desensitization rates. Peak current dose–response (solid) and binding (dashed) curves in color, with experimentally measured rates centrally (green), and slower (yellow and red) and faster (cyan, blue and purple) rates shifting respectively left and right. b Deterministic time courses with increasing ligand concentrations for the rates in (a). Plot shows all binding (normalized sum of all species with bound L-glutamate) and current (normalized species R1o), drawn with negative numbers vs. Time. Inset for higher desensitization rate shows the small peak current elicited by the higher ligand concentrations. c Binding time constant τ (τbinding) with base and factor-multiplied desensitization rates, as in (a). The inset shows the model diagram with the modified rate highlighted in green. d EC50 ratio between the steady state binding and peak current dose–response curves for the explored desensitization and resensitization rates. The inset shows the model diagram with the modified rates highlighted in green.
