Fig. 6: The effect of a changing desensitization rate is diminished but not eliminated by a transient input.
From: Modeling the use of transient ligand binding information by AMPA receptors
a Constant and transient glutamate (double exponential decay with time constants 100 μs and 2 ms, as in Clements et al.1), normalized to initial maximum concentration, normalized peak current elicited by each input, and normalized bound receptors. b Deterministic time courses with base desensitization rate with increasing ligand concentrations for constant and transient input with decay as in (a), with the time course corresponding to the EC50 concentration marked in black. Plot shows all binding (normalized sum of all species with bound L-glutamate) and current (normalized species R1o), drawn with negative numbers vs. time. c Peak current dose–response curves (solid) with base desensitization rate and constant (pink) or transitory (blue) ligand, steady state binding dose–response curve for constant ligand (dotted), peak binding and “binding at-current-peak” dose–response curve for transitory ligand (dashed and dash-dotted line). d Peak current dose–response curves with base and factor-multiplied desensitization rate. Peak current dose–response in color, with experimentally measured rates centrally (green), and slower (yellow and red) and faster (cyan, blue and purple) rates shifting respectively left and right. Inset shows the model diagram with the modified rate highlighted in green.
