Fig. 6: The value of kPB determines the stable equilibrium configuration of the system, which in turn governs the rate at which drug resistance develops.
From: The effect of stochastic noise on antibiotic resistance in intestinal flora
a kPB was increased by 0.1%. The green dashed line represented the slow manifold of the perturbed deterministic system. The black dot represented the steady state (healthy state) of the system, and the orange dot represented the initial point. b kPB was increased by 0.5%. c kPB was increased by 1%. d kPB was increased by 2%. e kPB was decreased by 0.1%. Here, the red, cyan, and blue curves represented the infection, antibiotic-treatment, and recovery courses, respectively. The inset panels marked the health state (red dots) transitions after each complete “infection-treatment-recovery” cycle. Panel (f) illustrated the divergent recovery trajectories of systems starting from identical post-treatment initial state, with (a–e) corresponding to the systems depicted in Panels (a–e), respectively.
