Fig. 2: Overview of the case study on scRNA-seq data-driven modeling of hematopoiesis. | npj Systems Biology and Applications

Fig. 2: Overview of the case study on scRNA-seq data-driven modeling of hematopoiesis.

From: Data-driven inference of Boolean networks from transcriptomes to predict cellular differentiation and reprogramming

Fig. 2

A Summary of the pipeline going from scRNA-seq data and DoRothEA interaction database to node selection and Boolean network variability analysis and clustering. B STREAM plot of scRNA-data after pseudo-trajectory reconstruction. The circle illustrate the selected start and end of branches from which cells where extracted and binarized. C Excerpt of the logical specification of Boolean network dynamical properties, expressed in the BoNesis language. D Result of gene ontology enrichment analysis on nodes selected by BoNesis. E Venn diagram showing the overlap of nodes of 3 Boolean networks of the literature with the nodes selected by BoNesis.

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