Table 2 Comparison of ROC AUC scores for classification of pathogenic vs. benign TTR variants

From: Integrative structural profiling and ligand optimisation across the transthyretin mutational landscape

Method

ROC AUC

E-SNPs&GO

0.4792

AlphaMissense

0.6771

VESM++a

0.9219

ESM2 + UMAPb

0.9948

  1. Thresholds: a0.2 for VESM++, b0.325 for ESM2+UMAP.
  2. Values highlighted in bold represent best results.
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