Fig. 1: 3D10 peptide array data mapped on their respective 3D protein structures. | npj Systems Biology and Applications

Fig. 1: 3D10 peptide array data mapped on their respective 3D protein structures.

From: Machine learning framework to extract physicochemical features of B-cell epitopes recognized by a cross-reactive antibody

Fig. 1

Structures generated by AlphaFold 3 (A, B) are accessible in a GitHub repository described in our data availability section. VAR2CSA (FCR3) structures were resolved by cryo-EM and are accessible at PDB ID 7JGE (C) and 7JGF (D)61. Raw median values are represented according to the colour scale and mapped to DBPII (A), PvEBP2 (B), VAR2CSA (FCR3) core region (DBL 1–4) (C), and VAR2CSA (FCR3) flexible arm region (DBL 5 and 6) (D). E One peptide within SD1 and four peptides recognized most strongly by 3D10 in VAR2CSA were selected for further analysis.

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