Fig. 3: Lysine adjacent to tyrosine and specific positive residue patterns result in strong 3D10 reactivity. | npj Systems Biology and Applications

Fig. 3: Lysine adjacent to tyrosine and specific positive residue patterns result in strong 3D10 reactivity.

From: Machine learning framework to extract physicochemical features of B-cell epitopes recognized by a cross-reactive antibody

Fig. 3

A–C Log odds ratio of distances between arginine to lysine, tyrosine to lysine, or lysine to lysine residues comparing observed proportion to expected value in 3D10 reactive and non-reactive peptides. Missing data points indicate a distance value occurred zero times and is significantly less common than expected (see Methods). D Table of peptide sequences with mutated residues coloured red. Peptides are grouped by different tests. E Mutated peptide reactivity relative to wildtype. Bars represent mean values plus standard deviation. Bars are coloured relative to their test group.

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