Fig. 1: Differential expression analysis on AGS cells after drug perturbations reveals significant shifts.
From: Constraint based modeling of drug induced metabolic changes in a cancer cell line
A Bar chart indicating the number of differentially expressed genes (DEGs) up- and down-regulated per treatment condition for all genes (left panel) and genes within the metabolic model Human-GEM (right panel). Significance was set using an adjusted p-value of <0.05, and an absolute log-FC > 1. B Scatter plots showing the distribution of DEGs across treatments for all genes (left panel) and genes within the metabolic model Human-GEM (right panel). The median is indicated using a red, horizontal line. C Venn diagrams for up- (left panel) and down-regulated (right panel) DEGs for the TAKi, PI3Ki and PI3Ki–TAKi treatments. D Venn diagrams for up- (left panel) and down-regulated (right panel) DEGs for the MEKi, PI3Ki and PI3Ki–MEKi treatments. Darker colours indicate a higher number of DEGs.
