Fig. 2: Gene Ontology gene set enrichment analysis summary.
From: Constraint based modeling of drug induced metabolic changes in a cancer cell line
A Bar chart indicating the number of significant gene sets up- and down-regulated per treatment condition. Significance was set using an adjusted p-value of <0.05, and an absolute normalised enrichment score (NES) > 1. B Scatter plot showing the distribution of DEGs across treatments for all genes. The median is indicated using a red, horizontal line. C and D Heatmaps of the top 15 significant gene sets in terms of significance and NES across all treatment conditions for up- and down-regulated gene sets, respectively. Bluer colours in the heatmap indicate lower, negative NES values, while redder colours indicate higher, positive NES values. White cells indicate that the specific gene set in a given condition was not statistically significant.
