Fig. 4: Synergistic effects over AGS metabolism trend towards down-regulation.
From: Constraint based modeling of drug induced metabolic changes in a cancer cell line
A Bar charts indicating the number of significant and synergistic metabolic tasks identified with TIDE in PI3Ki–TAKi and PI3Ki–MEKi. Synergy type is indicated in blue for down-regulated scores and in red for up-regulated. Non-synergistic and non-significant results are indicated in grey. B Distribution of significant metabolic scores between non-synergistic and synergistic metabolic tasks identified with TIDE in PI3Ki–TAKi and PI3Ki–MEKi. The mean is indicated with a horizontal, red line. P-values were obtained using a Mann–Whitney test. C Heatmap of strong synergies for either PI3Ki–TAKi or PI3Ki–MEKi. Scores for all treatment conditions are shown for comparison. Coloured bars indicate the metabolic system (leftmost) and the combinatorial treatment to which the synergy belongs. Panel D shows a heatmap of weak synergies for either PI3Ki–TAKi or PI3Ki–MEKi. Scores for all treatment conditions are shown for comparison. Coloured bars indicate the metabolic system (leftmost) and the combinatorial treatment to which the synergy belongs.
