Fig. 5 | npj Vaccines

Fig. 5

From: Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells

Fig. 5

Nano-11 facilitates the transport of antigens to lymph nodes. a Detection and phenotyping of OVA+ cells in the draining lymph nodes of mice injected with 10 µg Alexa Fluor 647-conjugated OVA alone or adjuvanted with either 200 μg AH or 200 μg Nano-11 on day 1 and day 2. Data are representative of experiments with six mice. b Mean fluorescence intensity of OVA in OVA-containing cells in the draining lymph node on day 1 and day 2 with mice injected with different formulations. Bars represent the mean ± SEM of six mice. *p < 0.05. c Percentage of MigDCs among OVA-positive cells in the draining lymph nodes of mice injected with different formulations. Bars represent the mean ± SEM of six mice. *p < 0.05

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