Fig. 6 | npj Vaccines

Fig. 6

From: Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells

Fig. 6

Nano-11 improves antigen targeting to immunopotentiating cells in the draining lymph node and increases retention of antigen at the injection site. a Expression of CD86 on different types of OVA+ cells in the lymph node. b Phenotyping of OVA+ and OVA− MigDCs in the draining lymph node. Lymph nodes were harvested 2 days after injection of 10 μg Alexa Fluor 647-labeled OVA adjuvanted with 200 μg Nano-11 and data are representative of two independent experiments. c Mice were injected with 10 μg of Alexa Fluor 647-conjugated OVA alone or adjuvanted with either AH or Nano-11 and examined with a fluorescence imager over time. Data are representative of two independent experiments

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