Fig. 4
Correlation between exposure types, effect of time on neutralisation titre, and comparison of TBEV and YFV vaccination titres. The geometric mean neutralisation titres for each virus were correlated based upon exposure type (Fig. 4a), with correlation analysis performed using a Log-Log non-linear curve fit in GraphPad Prism 7 (GraphPad, La Jolla, CA). Infectee and vaccine breakthrough donors who had multiple samples from different timepoints were analysed in a temporal manner (Fig. 4b) to determine whether neutralisation titres waned with time. Comparison of TBEV Hypr and YFV 17 vaccine-to-blood draw interval, as well as NT50 and PRNT50 values, were performed using a Log-Log non-linear curve fit (Fig. 4c). In addition, comparison of TBEV Hypr NT50 and YFV 17D PRNT50 neutralisation titres with the vaccine-to-blood draw interval was performed (Fig. 4d)
