Fig. 5
From: Protein nanovaccine confers robust immunity against Toxoplasma
T. gondii brain cysts luciferase expression was significantly reduced in immunized HLA-A*1101 mice. HLA-A*1101 transgenic mice were immunized with GLA-SE adjuvanted Empty-SAPN or CD8-SAPN three times at intervals of 2 weeks. PBS was used as control. a T. gondii brain cysts luciferase expression was significantly reduced in HLA-A*1101 mice immunized with CD8-SAPN plus GLA boost at 21 days after challenge with 2000 Me49 (Fluc) T. gondii expressing luciferase. b Xenogen imaging of brain ex vivo following the injection of luciferin into the retro-orbital plexus and then exposure of the brain to luciferin solution. This figure shows data from mice in one of the replicate experiments (n = 4 control and 4 immunized mice). c Enumeration of cyst was performed with brains of mice challenged 21 days after final immunization. SAPN reduced cyst numbers and luminescence (p < 0.05)
