Fig. 5

ILC and DC coordination is capable of enhancing T cell proliferation. a Flow cytometric analysis and comparison of CD94⁻CD45⁺CD127⁺Lin⁻ (ILCs) from skin and muscle at 12 h post inoculation. Data are representative of 3 separate experiments for each subset. b Specific IFN-γ proliferation of cocultured T cells and ILCs, T cells and DCs, and T cells, ILCs and DCs stimulated with EV71 antigen (left panel) and CA16 antigen (right panel) at 12 h post inoculation. c Specific IFN-γproliferation of cocultured T cells and ILCs, T cells and DCs, and T cells, ILCs and DCs stimulated with EV71 antigen (left panel) and CA16 antigen (right panel) at 24 h post inoculation. d mRNA expression profiles of skin from each group at 12 h post inoculation. All data from each control group (IM, ID) were treated as reference values to calculate the relative fold change. Data are representatives of three independent experiments (error bars represent SD). Statistical significance were assessed by unpaired t tests (*p < 0.01, **p < 0.001, ***p < 0.0001)