Table 3 Cross-clade HI antibody responses following prime-boost A(H5N1) vaccination
Study groups | Influenza A viruses | Subtype | HA clade | N | Pre-vaccination HI GMT (95% CI) | Post-vaccination HI GMT 95% CI | %with HI ≥40 post vaccination- SPR (95% CI) |
|---|---|---|---|---|---|---|---|
Group 1 (homologous) | A/turkey/Turkey/1/2005 | H5N1 | 2.2.1 | 35 | 5 (–) | 122 (77–194) | 86 (70–95) |
A/Indonesia/5/2005 | H5N1 | 2.1.3.2 | 35 | 5 (–) | 55 (34–88) | 69 (51–83) | |
A/Vietnam/1194/2004 | H5N1 | 1 | 35 | 6 (5–7) | 55 (36–84) | 71 (54–85) | |
A/Indonesia/NIHRD-12379/2012 | H5N1 | 2.1.3.2 | 35 | 5 (5–6) | 40 (26–62) | 63 (45–79) | |
A/Egypt/N04915/2014 | H5N1 | 2.2.1 | 35 | 5 (5–6) | 43 (27–68) | 66 (48–81) | |
A/duck/Bangladesh/19097/2013 | H5N1 | 2.3.2.1a | 35 | 5 (5–6) | 42(27–66) | 66 (48–81) | |
A/duck/Vietnam/NCVD-1584/2012 | H5N1 | 2.3.2.1c | 35 | 5 (–) | 36 (22–56) | 57 (39–74) | |
A/gyrfalcon/Washington/410886/2014 | H5N8 | 2.3.4.4 | 35 | 5 (–) | 15 (10–22) | 26 (12–43) | |
|  | A/turkey/Turkey/1/2005 | H5N1 | 2.2.1 | 35 | 5 (–) | 148 (94–234) | 83 (66–93) |
Group 2 (heterologous-high dose) | A/Indonesia/5/2005 | H5N1 | 2.1.3.2 | 35 | 5 (5–6) | 145 (93–226) | 83 (66–93) |
A/Vietnam/1194/2004 | H5N1 | 1 | 35 | 5 (5–6) | 61 (41–89) | 77 (60–90) | |
A/Indonesia/NIHRD-12379/2012 | H5N1 | 2.1.3.2 | 35 | 5 (5–6) | 109 (69–171) | 83 (66–93) | |
A/Egypt/N04915/2014 | H5N1 | 2.2.1 | 35 | 6 (5–7) | 53 (36–76) | 71 (54–85) | |
A/duck/Bangladesh/19097/2013 | H5N1 | 2.3.2.1a | 35 | 5 (5–6) | 61 (42–89) | 80 (63–92) | |
A/duck/Vietnam/NCVD-1584/2012 | H5N1 | 2.3.2.1c | 35 | 5 (5–6) | 56 (37–84) | 74 (57–88) | |
A/gyrfalcon/Washington/410886/2014 | H5N8 | 2.3.4.4 | 35 | 5 (–) | 23(16–32) | 40 (24–58) | |
|  | A/turkey/Turkey/1/2005 | H5N1 | 2.2.1 | 35 | 6 (5–6) | 168 (110–257) | 94 (81–99) |
Group 3 (heterologous-low dose) | A/Indonesia/5/2005 | H5N1 | 2.1.3.2 | 35 | 5 (–) | 155 (99–243) | 91 (77–98) |
A/Vietnam/1194/2004 | H5N1 | 1 | 35 | 6 (5–7) | 75 (50–115) | 80 (63–92) | |
A/Indonesia/NIHRD-12379/2012 | H5N1 | 2.1.3.2 | 35 | 5 (–) | 119 (77–184) | 89 (73–97) | |
A/Egypt/N04915/2014 | H5N1 | 2.2.1 | 35 | 5 (5–6) | 51 (33–77) | 71 (54–85) | |
A/duck/Bangladesh/19097/2013 | H5N1 | 2.3.2.1a | 35 | 5 (–) | 68 (46–102) | 74 (57–88) | |
A/duck/Vietnam/NCVD-1584/2012 | H5N1 | 2.3.2.1c | 35 | 5 (–) | 64 (41–100) | 69 (51–83) | |
A/gyrfalcon/Washington/410886/2014 | H5N8 | 2.3.4.4 | 35 | 5 (–) | 24 (15–37) | 34 (19–52) |
