Fig. 6
From: An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses
Role of T cells in host protection following vaccination with ZIKV mutants. a, b Six-week-old AB6 mice were infected i.p. with 2 × 104 FFU ZIKV NS4B-C100S (C100S) or ZIKV-3′UTR-Δ10 (Δ10). (a) Mouse weight loss and (b) survival rate. Weight loss is indicated by percentage, using the weight on the day before immunization to define 100%. n = 10 for each group. c, d On days 26 and 27, vaccinated mice were either depleted of CD4+ and CD8+ T cells or injected with PBS followed by challenge with 2 × 105 PFU WT ZIKV FSS13025ic on day 28. (c) Mouse weight loss and (d) survival rate. Weight loss is indicated by percentage, using the weight on the day before immunization to define 100%. n = 5 for each group. **P < 0.01 compared with mock group (log-rank test).
