Fig. 3: Correlation between the inhibition ratio by mAbs and neutralization titer of the vaccinated guinea pig sera. | npj Vaccines

Fig. 3: Correlation between the inhibition ratio by mAbs and neutralization titer of the vaccinated guinea pig sera.

From: Structural characterization of a neutralizing mAb H16.001, a potent candidate for a common potency assay for various HPV16 VLPs

Fig. 3

Correlation between BID50 and ID50 for H16.001 (a), H16.8A9 (b), H16.V5 (c), and H16.4G12 (d). ID50 was defined as the serum dilution required to block viral entry by 50%. BID50 was defined as the serum dilution required to block specific mAb binding by 50%. The black dots represent sera from guinea pigs vaccinated with Y1.16 VLPs produced by yeast expression system, the red ones represent sera with Y2.16 by yeast expression system, the green ones represent sera with E1.16 by E. coli expression system, the blue ones represent sera with E2.16 by E. coli expression system, and the purple ones represent sera with I1.16 by insect cell expression system. The comparison was assessed using the calculated Pearson coefficient of correlation, and the statistical analysis was performed using GraphPad Prism 7.

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