Table 3 Summary of samples used in MGIA studies.
From: A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates
Study | Species | Groups (n) | BCG vaccination | In vivo challenge | Refs. |
|---|---|---|---|---|---|
1 | Cynomolgus, Mauritian Female 14.3–15.6 years | BCG ID (8) | BCG Danish (SSI) 2–8 × 105 CFU | BCG Danish (SSI) 1–4 × 106 CFU ID route 21 weeks post-BCG | |
2 | Rhesus, Indian Female 14.3–15.6 years | Naïve controls (6) BCG ID (6) | BCG Danish (SSI) 2–8 × 105 CFU | BCG Danish (SSI) 2–8 × 105 CFU ID route 21 weeks post-BCG | |
3 | Rhesus, Chinese Male 2.5–3.4 years | Naïve controls (9) BCG ID (15) | BCG Danish (SSI) 2–8 × 105 CFU | M.tb Erdman strain K01 (Aeras) 500 CFU Endobronchial instillation route 38 weeks post-BCG | n/a |
4 | Rhesus, Indian Male 2.1–2.8 years | Naïve controls (6) BCG ID (6) BCG ID + IT (6) BCG IV (6) | BCG Danish (SSI) 2–8 × 105 CFU ID 2–8 × 105 CFU ID + 2–8 × 106 CFU IT 2–8 × 106 CFU IV | M.tb Erdman strain K01 (BEI) 100 CFU Aerosol route 21 weeks post-BCG |
