Table 1 Cell profiles within fluid recovered from diffusion chambers implanted in BALB/cByJ and 8 CC-RIX Lines.

From: Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice

 

BALB/cByJ

A

B

D

F

H

M

R

W

NK Cells

9433* [2×]

7273

3594

3112* [3×]

1398

2442

1888

396

1699

(5411, 28,981)

(4579, 13,442)

(392, 84,492)

(2428, 13,948)

(696, 2279)

(1841, 4371)

(1557, 2066)

(206, 819)

(1132, 3739)

Dendritic Cells

279

1343

745

636* [4×]

579

535

1023

248

1300

(188, 525)

(929, 3759)

(104, 23,065)

(445, 1726)

(335, 1156)

(394, 1104)

(527, 1082)

(183, 409)

(880, 2019)

Neutrophils

14042* [3×]

11740

1315

11298* [7×]

2133

6204

305

307

4494

(4134, 43,746)

(6297, 31,143)

(313, 151,125)

(8620, 35,869)

(606, 5372)

(3440, 11373)

(174, 616)

(224, 1365)

(1995, 7593)

Eosinophils

440

68

14

148

108

433

86

27

14

(181, 970)

(41, 136)

(13, 54)

(27, 256)

(54, 136)

(102, 1032)

(66, 122)

(17, 32)

(14, 20)

Monocytes

315* [1.4×]

79

122

271

54

165

68

31

67

(150, 2234)

(54, 150)

(0, 875)

(202, 835)

(27, 135)

(89, 1064)

(33, 135)

(19, 82)

(41, 108)

Macrophages

300

914

1043

1279* [9×]

121

837

623

49

1124

(189, 1050)

(604, 4385)

(13, 1538)

(459, 1845)

(67, 691)

(526, 1320)

(336, 698)

(27, 123)

(807, 2912)

T Cells

1480* [2×]

951

678

499

496

777

223

479

284

(724, 2424)

(590, 1376)

(418, 5551)

(284, 988)

(364, 686)

(660, 983)

(169, 321)

(433, 638)

(264, 902)

B Cells

534* [2×]

573

532

406

393

308

95

126

183

(291, 927)

(302, 1117)

(26, 4183)

(325, 2302)

(175, 638)

(161, 488)

(61, 183)

(56, 362)

(75, 251)

Total Cells

36903* [3×]

21687

9154

15384* [5×]

6705

12746

4409

1691

10418

(17,671, 75,443)

(15,619, 52,068)

(1266, 483,136)

(12,519, 60,147)

(2368, 10,286)

(7575, 24,950)

(3560, 4586)

(1533, 3369)

(8359, 13,193)

  1. Single cell suspensions were prepared from fluid recovered from diffusion chambers, stained using fluorescent antibodies and analyzed by flow cytometry. Median cell counts (number of cells per diffusion chamber) and interquartile ranges for total number of cells and for the 8 different cell types recovered from immunized CC-RIX and BALB/cByJ mice is presented. When a significant difference between control and immunized mice was observed, the fold increase in immunized mice over control mice is provided [×]. *statistically significant, p ≤ 0.05, when comparing results from control mice to vaccinated mice within each strain/line.
  2. The bold values indicate the statistically significant values.
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