Table 1 nOPV2-CD is attenuated in a mouse neurovirulence model.

From: Development of a new oral poliovirus vaccine for the eradication end game using codon deoptimization

Virus

PD50 [log10 CCID50 (95% CI)]a

Passage 0

Passage 10

MEF-1

0.8 (0.3–1.3)

ND

Sabin OPV2

5.6 (5.0–6.2)

2.1 (1.6–2.6)

nOPV2-CD

6.3 (5.9–6.8)

5.4 (5.0–5.8)

  1. ND not determined.
  2. aDose (as measured by CCID50) required to paralyze 50% of mice (PD50) was calculated using the Spearman-Karber method and 95% CI reported. n = 8 weight- and sex-matched mice per group.
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