Table 2 Genetic stability of viruses following serial passage in Vero cells.
From: Development of a new oral poliovirus vaccine for the eradication end game using codon deoptimization
Viral gene | Nucleotide positiona | Variant | Coding impact | Variant percentageb | |
|---|---|---|---|---|---|
Sabin OPV2 | nOPV2-CD | ||||
None (5′ UTR) | 156 | T to C | None | — | 7.5 |
None (5′ UTR) | 481 | A to G | None | 18.6 | — |
VP1 | 2797 | T to A | S106T | 13.3 | — |
3 C | 5774 | A to T | Y113F | 77.1 | 11.3 |
