Fig. 2: Antigen-specific CD4+ and CD8+ T cell in the lung measured for different ChAd 3-5Ag vaccine doses. | npj Vaccines

Fig. 2: Antigen-specific CD4+ and CD8+ T cell in the lung measured for different ChAd 3-5Ag vaccine doses.

From: Evaluation of heterologous prime-boost vaccination strategies using chimpanzee adenovirus and modified vaccinia virus for TB subunit vaccination in rhesus macaques

Fig. 2

a Percentage of CD4+ or b CD8+ T cells from lung washes (BAL), producing either IFN-γ, TNF-α, and/or IL-2 (in total) after antigen-specific ex vivo stimulation with peptide pools of individual antigens contained in the respective viral vector constructs. BAL samples were collected before vaccination (PRE), 4 weeks after ChAd3-5Ag priming (study week WK4), ChAd3-5Ag boosting (study week WK14) and MVATG18633 (108 PFU) boosting (study week Wk28). vp viral particles. The box extends from the 25th to 75th percentiles. The line in the middle signifies the median and the whiskers include the smallest value up to the largest.

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