Fig. 2: Statistics for ZIKV responses and challenge. | npj Vaccines

Fig. 2: Statistics for ZIKV responses and challenge.

From: The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates

Fig. 2

a Boosting with 108 pfu of SCV-ZIKA/CHIK on day 35 (after the initial vaccination with 108 pfu of SCV-ZIKA/CHIK) resulted in a significant increase in neutralising antibody responses (statistics by paired t-test). Each line represents a single NHP. The mean fold change (FC) in titres was 5.5 ± SEM 1.4. For NHPs receiving a single vaccination with 107 pfu of SCV-ZIKA/CHIK on day 0, there was no significant change in titres between day 35 and day 70. b SCV-ZIKA/CHIK vaccination provides significant protection against viremia using area under the curve calculations (statistics by Kolmogorov–Smirnov tests). c Anti-ZIKV-neutralising antibody responses inversely correlate with ZIKV load. Statistics by Spearman’s rank correlation test.

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